Bioethicists teaching and writing about the uses of prenatal genetic testing sometimes use “difficult cases” in which people with a disability want to test and select for the presence of their disability. Such cases challenge our stereotypes but also play into them.

To prepare for potential human infection challenge studies involving SARS-CoV-2, we convened a multidisciplinary working group to address ethical questions regarding whether and how much SAR...

In this article, using the recent work by Charles Taylor in A Secular Age as my point of departure, I will argue that Jean-Luc Nancy enables us to think past the competing binary of atheistic and religious experience and allows us to surpass the present narratives of secularism. In A Secular Age, Taylor himself seeks a middle ground between atheism and religion, arguing that it is possible to open ourselves to the cross-pressures of modern existence that find us caught between (...) scientific atheism and a need for spiritual and religious guidance. Here, Taylor finds a way of picturing ourselves within a secular age, remaining faithful to scientific rationalism, but still open to religion and a sense of a higher good. However, as I shall demonstrate, in his thesis Taylor misrepresents the Continental philosophical tradition (particularly Nietzsche and post-structuralism) that has itself sought to understand these cross-pressures of existence. Taking this misrepresentation, and specifically his reductive and colloquial analysis of Nietzsche, Camus, and Derrida, as my point of departure, I provide an alternative manner of thinking through the work of these writers, one that leads to a detailed analysis of Jean-Luc Nancy and his project the deconstruction of Christianity. In this analysis I argue that Nancy provides a manner of thinking that remains open and allows an experience of freedom, without seeking to close that sense of openness with explanation, nor maintaining that sense of openness with a conception of the divine. (shrink)

College students from small, medium, and large institutions with either a modified or no honor code were presented with cheating scenarios and asked to rate how dishonest they perceived the behavior to be and the likelihood that they would report it. No main effects were found for institution size or type of honor code. Student–faculty ratio was not correlated with responses to the cheating scenarios. Students from modified honor code schools perceived more severe punishments for cheating and understood the reporting (...) process better than students from non–honor code schools. Implications for modified honor code systems are discussed. (shrink)

Rare genetic diseases collectively impact millions of individuals in the United States. These patients and their families share many challenges including delayed diagnosis, lack of knowledgeable providers, and limited economic incentives to develop new therapies for small patient groups. As such, rare disease patients and families often must rely on advocacy, including both self-advocacy to access clinical care and public advocacy to advance research. However, these demands raise serious concerns for equity, as both care and research for a given disease (...) can depend on the education, financial resources, and social capital available to the patients in a given community. In this article, we utilize three case examples to illustrate ethical challenges at the intersection of rare diseases, advocacy and justice, including how reliance on advocacy in rare disease may drive unintended consequences for equity. We conclude with a discussion of opportunities for diverse stakeholders to begin to address these challenges. (shrink)

To address growing concerns about academic integrity, college students (n?=?758) at honor system and non-honor system institutions were presented with eight scenarios to determine the influence of an honor system on their perceptions of and responses to academic dishonesty. Main effects for honor code status emerged. Students from traditional honor system schools considered the behaviors to be more dishonest, and were more likely to respond that they would report the incident when compared to students attending modified and non-honor system institutions. (...) Findings suggest traditional honor systems, with specific rules and regulations in place, are more effective at cultivating academic integrity among students; modified honor systems may not be as effective as previous research suggests. (shrink)

Newborn bloodspot screening programs are some of the longest running population screening programs internationally. Debate continues regarding the need for parents to give consent to having their child screened. Little attention has been paid to how meanings of consent-related terminology vary among stakeholders and the implications of this for practice. We undertook semi-structured interviews with parents, healthcare professionals and policy decision makers in two Canadian provinces. Conceptions of consent-related terms revolved around seven factors within two broad domains, decision-making and information (...) attainment. Decision-making comprised: parent decision authority; voluntariness; parent engagement with decision-making; and the process of enacting choice. Information ascertainment comprised: professional responsibilities ; parent responsibilities; and the need for discussion and understanding prior to a decision. Our findings indicate that consent-related terms are variously understood, with substantive implications for practice. We suggest that consent procedures should be explained descriptively, regardless of approach, so there are clear indications of what is expected of parents and healthcare professionals. Support systems are required both to meet the educational needs of parents and families and to support healthcare professionals in delivering information in a manner in keeping with parent needs. (shrink)

The peer commentaries on our Target Article, “Promoting Ethical Payment in Human Infection Challenge Studies,” offer a number of insights that will help advance the co...

BackgroundDeveloping a comprehensive, reproducible literature search is the basis for a high-quality systematic review (SR). Librarians and information professionals, as expert searchers, can improve the quality of systematic review searches, methodology, and reporting. Likewise, journal editors and authors often seek to improve the quality of published SRs and other evidence syntheses through peer review. Health sciences librarians contribute to systematic review production but little is known about their involvement in peer reviewing SR manuscripts.MethodsThis survey aimed to assess how frequently librarians (...) are asked to peer review systematic review manuscripts and to determine characteristics associated with those invited to review. The survey was distributed to a purposive sample through three health sciences information professional listservs.ResultsThere were 291 complete survey responses. Results indicated that 22% (n = 63) of respondents had been asked by journal editors to peer review systematic review or meta-analysis manuscripts. Of the 78% (n = 228) of respondents who had not already been asked, 54% (n = 122) would peer review, and 41% (n = 93) might peer review. Only 4% (n = 9) would not review a manuscript. Respondents had peer reviewed manuscripts for 38 unique journals and believed they were asked because of their professional expertise. Of respondents who had declined to peer review (32%, n = 20), the most common explanation was “not enough time” (60%, n = 12) followed by “lack of expertise” (50%, n = 10).The vast majority of respondents (95%, n = 40) had “rejected or recommended a revision of a manuscript| after peer review. They based their decision on the “search methodology” (57%, n = 36), “search write-up” (46%, n = 29), or “entire article” (54%, n = 34). Those who selected “other” (37%, n = 23) listed a variety of reasons for rejection, including problems or errors in the PRISMA flow diagram; tables of included, excluded, and ongoing studies; data extraction; reporting; and pooling methods.ConclusionsDespite being experts in conducting literature searches and supporting SR teams through the review process, few librarians have been asked to review SR manuscripts, or even just search strategies; yet many are willing to provide this service. Editors should involve experienced librarians with peer review and we suggest some strategies to consider. (shrink)

William E. Connolly, A World of Becoming Content Type Journal Article Category Book Review Pages 138-141 Authors Alexander C. Karolis, School of Philosophy, Research School of Social Sciences, Australian National University Journal Critical Horizons: A Journal of Philosophy & Social Theory Online ISSN 1568-5160 Print ISSN 1440-9917 Journal Volume Volume 13 Journal Issue Volume 13, Number 1 / 2012.

Preface, by F. L. Windolph.--A modern concept of God, by A. H. Compton.--The immortality of man, by J. Maritain.--The idea of God in the mind of man, by M. Royden.--Psychical research and the life beyond death, by H. Hart.--Religion and modern knowledge, by R. Niebuhr.--Immortality in the light of science and philosophy, by W. E. Hocking.--"To whom shall ye liken God?" By C. E. Park.--Man's destiny in eternity, by W. L. Sperry.--The idea of God as affected by modern knowledge, by (...) F. S. C. Northrop. (shrink)

Already an admired senior poet to Virgil in the Eclogues , Varius by the mid-thirties, B.C. had established himself as the leading epic writer of his day . It is a sobering thought that we do not know even the titles of the serious hexameter works which had won him so high a reputation, except for de Morte, quoted four times by Macrobius.

Moti Mizrahi provides experimental evidence according to which subjects judge that a person ought to ? even when she cannot ?. He takes his results to constitute a falsification of the alleged intuitiveness of the ‘Ought Implies Can’ principle. We point out that in the light of the fact that (a) ‘ought’ is multiply ambiguous, that (b) only a restricted set of readings of ‘ought’ will be relevant to the principle, and that (c) he did not instruct his subjects appropriately (...) – or otherwise ensure that in their ‘ought’ judgements they applied the relevant concept(s) – Mizrahi’s conclusions appear premature. We suggest two ways in which the experimental design could be adjusted or supplemented. First, Mizrahi could instruct (or prime) subjects to read the ‘ought’ question in a particular way. Second, he could complement his experiment by asking follow-up questions aimed at uncovering the implications for blame of subjects’ judgements. Once these adjustments are applied, an experiment with a similar outcome would be more significant. (shrink)

Michael Choniates (c. 1138–c. 1222), a pupil of Eustathius of Thessalonica, who was Greek Orthodox Metropolitan of Athens for some 25 years up to that city's capture by Frankish crusaders ina.d.1205, is best known to classical scholars as the possessor of probably the last complete copy of Callimachus'HecaleandAetia. He had brought with him from Constantinople many books of all kinds, and added to his collection when in Athens. Although an immense task, it would be well worth trying to identify all (...) Michael's classical allusions, as an indication of how much ancient Greek literature was still available just before Constantinople too succumbed to the crusaders. (shrink)

Some scholars have seen in ‘fulminat’ an allusion to Callimachus' βροντν οκ μν, λλ Διc , and that is reasonable enough, since Virgil contrasts the warlike fulminations of Octavian with mocking disparagement of his own very different lifestyle . But it may have escaped attention that Virgil seems to be imitating some lines by another Hellenistic poet, Rhianus ; the parallel has thought-provoking implications.

Racism is a pervasive issue in patient care and a key social determinant of health. Clinical ethicists, like others involved in patient care, have a duty to recognize and respond to racism on both individual and systems-wide levels to improve patient care. Doing so can be challenging and, like other skills in ethics consultation, may benefit from specialized training, standardized tools and approaches, and practice. Learning from existing frameworks and tools, as well as building new ones, can help guide clinical (...) ethicists to systematically approach racism as it affects clinical cases. Here, we propose an expansion of the commonly used four-box method to clinical ethics consultation, where racism is considered as a potential factor in each of the four boxes. We apply this method to two clinical cases to highlight ethically salient information that might be missed using the standard formulation of the four boxes but captured with the expanded version. We argue that this expansion of an existing clinical ethics consultation tool is ethically justified insofar as it (a) creates a more just approach, (b) supports individual consultants and services, and (c) facilitates communication in contexts where racism impinges on effecting good patient care. (shrink)

The Latin text is established from the first edition of the Epistola and Hollis' edition. Since the author regards Popple's English translation, which is here edited and reprinted en regard, as having been supervised and approved by Locke himself, it is taken to be as authoritative as the Latin and accordingly is used in establishing the Latin text. The translation is established from its first and second editions. Montuori has not always indicated his departures from Locke's spelling and punctuation, (...) although the pagination of the collated texts is indicated in the margin. Locke's second and third Letters Concerning Toleration are not reprinted here.—H. C. (shrink)

In Hollis’ paradox, A and B each chose a positive integer and whisper their number to C. C then informs them, jointly, that they have chosen different numbers and, moreover, that neither of them are able to work out who has the greatest number. A then reasons as follows: B cannot have 1, otherwise he would know that my number is greater, and by the same reasoning B knows that I don’t have 1. But then B also cannot have (...) 2, otherwise he would know that my number is greater (since he knows I don’t have 1). This line of reasoning can be repeated indefinitely, effectively forming an inductive proof, ruling out any number – an apparent paradox. In this paper we formalise Hollis’ paradox using public announcement logic, and argue that the root cause of the paradox is the wrongful assumption that A and B assume that C’s announcement necessarily is successful. This resolves the paradox without assuming that C can be untruthful, or that A and B are not perfect reasoners, like other solutions do. There are similarities to the surprise examination paradox. In addition to a semantic analysis in the tradition of epistemic logic, we provide a syntactic one, deriving conclusions from a set of premises describing the initial situation – more in the spirit of the literature on Hollis’ paradox. The latter allows us to pinpoint which assumptions are actually necessary for the conclusions resolving the paradox. (shrink)

Volume 19, Issue 5, May 2019, Page 72-74.

This paper compares the heuristic potential of three metaphorical paired concepts used in the relevant literature to characterise global relationships between the anthroposphere and the ecosphere. Methodologically, the guiding question is whether and to what extent metaphorical theses can support an arrival at hypotheses which accurately reflect reality and possess explanatory force. The predator-prey model implies that the populations of two species in such a relationship in principle exhibit coupled oscillations, giving prey populations the possibility of periodic regeneration. For some (...) time, however, the most important indicators of human destruction of nature have been showing a relentless upward trend which appears to render the tumour-host metaphor more appropriate. Another fact which favours this analogy is that a tumour develops within its host and from its host's normal cells, in a similar way to the emergence of the anthroposphere from within the biosphere. But the parasite-host analogy also allows the formulation of fruitful hypotheses, since ecological parasitology is equally familiar with varieties of autoaggressive interaction and provides a means of focusing particularly on the adelphoparasitic hierarchy within the anthroposphere. (shrink)

In this field guide, I distinguish five separate senses with which the term ‘mechanism’ is used in contemporary philosophy of science. Many of these senses have overlapping areas of application but involve distinct philosophical claims and characterize the target mechanisms in relevantly different ways. This field guide will clarify the key features of each sense and introduce some main debates, distinguishing those that transpire within a given sense from those that are best understood as concerning distinct senses. The ‘new mechanisms’ (...) sense is at the center of most of these contemporary debates and will be treated at greater length; subsequent senses of mechanism will be primarily distinguished from this one. In part I of this paper, I distinguish two senses of the term ‘mechanism’, both of which are explicitly hierarchical and nested in character, such that any given mechanism is comprised of smaller sub-mechanisms, in turn comprised of yet smaller sub-sub-mechanisms and so on. While both of the senses discussed here are anti-reductive, they differ in their focus on scientific practice versus metaphysics, in the degree of regularity they attribute to mechanisms, and in terms of their relationships to the discussions of mechanisms in the history of philosophy and science. (shrink)

This paper articulates an account of causation as a collection of information-theoretic relationships between patterns instantiated in the causal nexus. I draw on Dennett’s account of real patterns to characterize potential causal relata as patterns with specific identification criteria and noise tolerance levels, and actual causal relata as those patterns instantiated at some spatiotemporal location in the rich causal nexus as originally developed by Salmon. I develop a representation framework using phase space to precisely characterize causal relata, including their degree (...) of counterfactual robustness, causal profiles, causal connectivity, and privileged grain size. By doing so, I show how the philosophical notion of causation can be rendered in a format that is amenable for direct application of mathematical techniques from information theory such that the resulting informational measures are causal informational measures. This account provides a metaphysics of causation that supports interventionist semantics and causal modeling and discovery techniques. (shrink)

Even though the evidence‐based medicine movement (EBM) labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong in two examples where mechanistic reasoning failed to generate accurate predictions for how a dysfunctional mechanism would respond to intervention. (...) I then use these examples to explain why we should expect this kind of mechanistic reasoning to fail in systematic ways, by situating these failures in terms of evolved complexity of the causal system(s) in question. I argue that there is still a different role in which mechanisms continue to figure as evidence in EBM: namely, in guiding the application of population‐level recommendations to individual patients. Thus, even though the evidence‐based movement rejects one role in which mechanistic reasoning serves as evidence, there are other evidentiary roles for mechanistic reasoning. This renders plausible the claims of some critics of evidencebased medicine who point to the ineliminable role of clinical experience. Clearly specifying the ways in which mechanisms and mechanistic reasoning can be involved in clinical practice frames the discussion about EBM and clinical experience in more fruitful terms. (shrink)